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KMID : 1137820220430020094
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의공학회지
2022 Volume.43 No. 2 p.94 ~ p.101
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Effect of Specific Interaction of Multi-Ligands on the Specific Interaction between Particle and Cell
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Yoon Jung-Hyun
Lee Sei-Young
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Abstract
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Recent advancement of micro/nano technology enables the development of diverse micro/nano particle- based delivery systems. Due to the multi-functionality and engineerability, particle-based delivery system are expected to be a promising method for delivery to the target cell. Since the particle-based delivery system should be delivered to the various kinds of target cell, including the cardiovascular system, cancer cell etc., it is frequently decorated with multiple kinds of targeting molecule(s) to induce specific interaction to the target cell. The surface decorated molecules interact with the cell surface expressed molecule(s) to specifically form a firm adhesion. Thus, in this study, the probability of adhesion is estimated to predict the possibility to form a firm adhesion for the multi-ligand decorated particle-based delivery system.
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KEYWORD
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Drug delivery system, Specific interaction, Multi-ligand targeting, Probability of adhesion, Elastic spring model
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